Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis
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چکیده
منابع مشابه
Dmp1α Inhibits HER2/neu-Induced Mammary Tumorigenesis
Our recent study shows a pivotal role of Dmp1 in quenching hyperproliferative signals from HER2 to the Arf-p53 pathway as a safety mechanism to prevent breast carcinogenesis. To directly demonstrate the role of Dmp1 in preventing HER2/neu-driven oncogenic transformation, we established Flag-Dmp1α transgenic mice (MDTG) under the control of the mouse mammary tumor virus (MMTV) promoter. The mice...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2018
ISSN: 0950-9232,1476-5594
DOI: 10.1038/s41388-018-0439-1